- Perry the Platypus as Perry the Kid
- Peter "Hook" Johnson as Doc Scurlock
- Heinz Doofensmritz as Murphy Doofensmritz
- Dennis the Rabbit(Landry) as Richard "Dick" Brewer
- Terry the Turtle as Jose Chavez y Chavez
- Pinky the Chihuahua as Charlie Bowdre
- Herman the Hegdehog as "Dirty Steve" Stephens
- Derek the Dog as Buckshot Roberts
- Jake the Platypus as Pat Garrett
- John the Platypus as Alexander McSween
- Barry the Bulldog as John Tunstall
- Piper the Platypus as Susan McSween
Much of Platypus Guns's plot is currently being written. The only things known are Perry meeting Chavez and the McSween home shootout.
"Try and kill me." -Perry the Kid
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